Publications – Groupe « Dégénérescence maculaire et rétinopathie diabétique » / « Macular degeneration and diabetic retinopathy » group

Numéro ORCID (0000-0001-7440-2799)

Articles

Fresia D., Cannizzaro E., Borgo A. and Roduit R « GSH-Independent Induction of ER Stress during Hypoglycaemia in the Retinal Cells of Mice” J Clin Med. 2021 Jun; 10(11): 2529

Mantel I., Borgo A., Guidotti J., Forestier E., Kirsch O., Derradji Y., Waridel P., Burdet F., Mehl F., Schweizer C., and Roduit R. “Molecular Biomarkers of Neovascular Age-Related Macular Degeneration With Incomplete Response to Anti-Vascular Endothelial Growth Factor Treatment”. Front. Pharmacol., 2020. doi.org/10.3389/fphar.2020.594087

Pyakurel A., Balmer D., Saba El Leil M., Kizilyaprak C., Daraspe J., Humbel B., Le YZ., vonLintig J. Meloche S. and Roduit R. « Loss of ERK1/2 in the retinal pigment epithelium leads to RPE65 decrease and retinal degeneration. » Molecular and Cellular Biology, 37:e00295-17. 2017

Balmer D., Bapst-Wicht L., Pyakurel A., Emery M., Nanchen N., Bochet C.G., Roduit R. « Bis-Retinoid A2E Induces an Increase of Basic Fibroblast Growth Factor via Inhibition of Extracellular Signal-Regulated Kinases 1/2 Pathway in Retinal Pigment Epithelium Cells and Facilitates Phagocytosis. » Frontiers in Aging Neuroscience 9:43. 2017.

Emery M., Nanchen N., Preitner F., Ibberson, M, and Roduit R. « Biological characterization of genes response to insulin-induced hypoglycemia in mouse retina. » PLosONE 11(2): e0150266. 2016.

Mantel I., Ambresin A., Droz I., Roduit R., Faouzi M., Munier FL. and Schorderet D. « Complement Factor B Polymorphism and the Phenotype of Early Age-Related Macular Degeneration. » Ophthalmics Genetics 35(1):12-7. 2014.

Balmer D., Andreux P., Auwerx J., Puyal J., Puyal-Guinet V., Schorderet D. and Roduit R. « Autophagy defects is associated with low glucose-induced apoptosis in 661W photoreceptor cells. » PLosONE 8(9): e74162, 2013.

Métrailler S., Emery M., Schorderet D., Cottet S. and Roduit R. « Erk1/2 pathways is activated in degenerated RPE65-deficiente mice » Exp Eye res. 116C [Epub ahead of print] 2013.

Emery M., Schorderet DF. and Roduit R. « Acute Hypoglycemia Induces Retinal Cell Death in Mouse. » PLosONE 6(6): e21586, 2011.

*Joly E., *Roduit R., Peyot M-L., Habinowski SA., Ruderman N.B., Witters L.A. and Prentki M. « Glucose represses PPARa gene expression via AMP-activated protein kinase but not via p38 mitogen-activated protein kinase in the pancreatic b-cell. » Journal of Diabetes 1 : 263-272, 2009. (*equal contribution)

Roduit R., Escher P. and Schorderet D. « Mutations in the DNA-Binding Domain of NR2E3 affect in vivo dimerization and interaction with CRX. » PLosONE 4(10): e7379, 2009.

Escher P., Gouras P., Roduit R., Tiab L., Bolay S., Delarive T., Chen S., Tsai CC., Hayashi M., Zernant J., Merriam J E. , Mermod N., Allikmets R., Munier FL. and Schorderet DF. « Mutations in NR2E3 can cause dominant or recessive retinal degenerations in a same family. » Hum Mutat. 30(3):342-51, 2009.

Roduit R. and Schorderet DF. « MAP kinase pathways in UV-induced apoptosis of retinal pigment epithelium ARPE19 cells. »Apoptosis. 13(3): 343-53, 2008.

Meadler K., Bielmann C., Allaman-Pillet N., Beckman J., Bonny C., Donath M. and Roduit R. « Leptin and glucose induce b-cell apoptosis through activation of c-Jun N-terminal kinases (SAPK/JNK). » FASEB J.22: 1905-1913, 2008.

Guenat S., Rouleau N., Bielman C., Bedard J., Maurer F., Bonny C., Beckman J., Allaman-Pillet N., Nicod P., Bossé R. and Roduit R. « Homogenous and non-radioactive HTS platform for screening Kinase inhibitors in whole cells. » J Biomol Screen. 11(8): 1015-26, 2006.

Kristensen O., Guenat S., Allaman-Pillet N., Dar I., Kastrup J.E., Roduit R., Beckman J., Gajhede M. and Bonny C. « Structural basis for an novel SH3 domain dimerization involving the canonical PPII recognition site. » EMBO J. 25(4): 785-97, 2006.

*Gremlich S., *Nolan C., *Roduit R., Burcelin R. Peyot M-L. Delghingaro-Augusto V., Desvergne B., Michalik L., Prentki M. and Wahli W, « Pancreatic islet adaptation to fasting is dependent on peroxisome proliferator-activated receptor alpha transcriptional up-regulation of fatty acid oxidation. » Endocrinology 146(1): 375-82. 2005. (*equal contribution)

Joly E,.Bendayan M., Roduit R., Saha A.K., Ruderman N.B. and Prentki M. « MalonylCoA Decarboxylase is present in the cytosolic, in the mitochondrial and the peroxisomal compartments of rat hepatocytes. » FEBS letter. 579(29): 6581-6586, 2005.

Roduit R., Nolan C., Alarcón C., Kelpe C., Przybykowski E., Morin J., Massé F., Massie B., Ruderman N., Rhodes C.J. Poitout V. and Prentki M.. « A role for the Malonyl-CoA Decarboxylase/Long Chain Acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. » Diabetes 53:1007-1019, 2004.

Abdelli S., Ansite J., Roduit R., Borsello T., Matsumoto I., Sawada T., Allaman-Pillet N., Henry H., Beckmann J.S., Hering B. and Bonny C. « Intracellular Stress Signalling Pathways Activated During Human Islet Preparation And Following Acute Cytokine Attack. » Diabetes 53: 2815-2823, 2004.

Allaman-Pillet N., Roduit R., Oberson A., Ruiz J., Schorderet DF. and Bonny C. « Circadian regulation of islet genes involved in insulin production and secretion. » Molecular and Cellular Endocrinology 226: 59-66, 2004.

Allaman-Pillet N., Størling J., Oberson A., Roduit R., Negri S., Sauser C., Nicod P., Beckmann JS., Schorderet DF., Mandrup-Poulsen T. and Bonny C. « Calcium- and Proteasome-dependent Degradation of the JNK Scaffold Protein Islet-brain 1. » J Biol. Chem. 278(49):48720-48726, 2003.

El-Assaad, W., Buteau, J., Peyot, ML., Hardy, S., Roduit R., Joly, E., Dbaibo, G., Rosenberg, L. and Prentki, M. « Elevated glucose and fatty acids synergized to causing b-cell death. » Endocrinology 144: 4154-4163, 2003.

Wu Y., Han B., Luo H., Roduit R., Zhang J. and Wu J. « DcR3/TR6 Effectively prevents Islet Primary Nonfunction after Transplantation. » Diabetes 52: 2279-2286, 2003.

Prentki M., Joly E., El-Assaad W. and Roduit R. « Malonyl-CoA Signaling, Lipid Partitioning, and Glucolipotoxicity: Role in beta-Cell Adaptation and Failure in the Etiology of Diabetes. » Diabetes Suppl 3: S405-13, 2002.

Roh C., Roduit R., Thorens B., Fried S. and Kandror K.V. « Lipoprotein lipase and leptin are accumulated in different secretory compartments in rat adipocytes. » J Biol. Chem. 276(38): 35990-35994, 2001.

*Roduit R., *Masiello P., *Wang S Li, H., Mitchell G. A. and Prentki M. « A role for hormone sensitive lipase in glucose-stimulated insulin secretion.«  Diabetes 50: 1970-1975, 2001. (*equal contribution)

Prentki M., Roduit R., Corkey B.E., Lameloise N. and Assimacopoulos-Jeannet F. « Glucotoxicity, lipotoxicity and ß-cell function in diabetes : A role for altered lipid partitioning. » Can J. Diabetes Care 25(1): 36-46, 2000.

Saha AK., Schwarsin AJ., Roduit R., Masse F., Kaushik V., Tornheim K., Prentki M. and Ruderman NB. « Activation of malonyl-CoA decarboxylase in rat skeletal muscle by contraction and the AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-beta -D-ribofuranoside. » J. Biol. Chem. 275(32): 24279-83, 2000.

Roduit R., Morin J., Masse F., Segall L., Roche E., Newgard CB., Assimacopoulos-Jeannet F. and Prentki M. « Glucose down regulates the expression of the PPARgene in the pancreatic b-cell. » J. Biol. Chem. 275(46): 35799-06, 2000.

Buteau J., Roduit R. and Prentki M. « GLP-1 promotes DNA synthesis, activates PI3-kinase and increases pdx-1 DNA binding activity in b(ins-1)-cells. » Diabetologia 42(7): 856-854, 1999.

Voilley N., Roduit R., Vicaretti R., Bonny C., Waeber G., Dyck J.R.B., Lopaschuk G.D. and Prentki M. « Cloning and expression of rat pancreatic b-cell malonyl-CoA decarboxylase. » Biochem. J. 340(1): 213-217, 1999.

Pralong F.P., Roduit R., Waeber G., Mosimann F., Rey F., Thorens B. and Gaillard R.C. « Evidence that leptin participates in the regulation of glucocorticoid production by the adrenal gland. » Endocrinology. 139(10): 4264-4268, 1998.

Bonny C., Roduit R., Gremlich S., Nicod P., Thorens B. and Waeber G. « The loss of GLUT2 expression in the pancreatic beta-cells of diabetic db/db mice is associated with an impaired DNA-binding activity of islet-specific trans-acting factors. »Mol. Cell Endocrinol. 135(1):59-65, 1997.

Gremlich S., Roduit R. and Thorens B. « Dexamethasone induces posttranslational degradation of GLUT2 and inhibition of insulin secretion in isolated pancreatic beta cells. Comparison with the effects of fatty acids. » J Biol. Chem. 272(6):3216-3222, 1997.

Waeber G., Calandra T., Roduit R., Haefliger J-A., Bonny C., Thompson N., Thorens B., Temler E., Meinhardt A., Bacher M., Metz C.N., Nicod P. and Bucala R. « Insulin secretion is regulated by the glucose-dependent production of islets b-cell macrophage migration inhibitory factor. » Proc. Natl. Acad. Sci. USA 94: 4782-4787, 1997.

Roduit R. and Thorens B. « Inhibition of insulin secretion by long-term exposure of pancreatic islets to leptin. » FEBS letter. 415(2): 179-182, 1997.

Thorens B. and Roduit R. « Regulated expression of GLUT2 in diabetes studied in transplanted pancreatic beta cells. » Biochem Soc Trans. 22(3):684-7, 1994.

Book chapters

Roduit R., Balmer D., Ibberson M. and Schorderet D.F. « Hypoglycemia and retinal cell death. », in Handbook of Nutrition, Diet and Eye, Ed. Victor R. Preedy, Elsevier, 2014.

Roduit R. and Schorderet DF. « Ischémie et atteinte neuronale: Apoptose. « , in Pathologies vasculaires oculaires, Ed. C Pournaras. Masson, Masson, Issy-les Moulinaeaux, 2008.

Allaman-Pillet N., Roduit R., Produit-Zengaffinen N. and Schorderet DF. « Perspectives thérapeutiques : modulation de l’apoptose à l’aide de peptides intracellulaire. » in Pathologies vasculaires oculaires, Ed. C Pournaras. Masson, Masson, Issy-les Moulinaeaux, 2008.

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